Wellbutrin XL extended-release bupropion hydrochloride tablets: Do not chew, cut, or crush tablets since this may lead to an increased risk of adverse effects including seizures. Administer once daily, preferably in the morning. DESCRIPTION. WELLBUTRIN XL® (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. DESCRIPTION. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect. Medscape - Depression, smoking cessation-specific dosing for Wellbutrin XL, Zyban (bupropion), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Major Depressive Disorder. Wellbutrin XL ® (bupropion hydrochloride extended-release tablets) is indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM). Contraindications • Wellbutrin is contraindicated in patients with a seizure disorder. • Wellbutrin is contraindicated in patients with a current or prior diagnosis of bulimia or anorexia nervosa as a higher incidence of seizures was observed in such patients treated with Wellbutrin [see Warnings and Precautions (5.3)]. • Wellbutrin is contraindicated in patients undergoing abrupt. Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used to treat major depressive disorder and to support stopping smoking. It is an effective antidepressant on its own, but is also used as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. WebMD provides common contraindications for Wellbutrin Oral. Find out what health conditions may be a health risk when taken with Wellbutrin Oral Find out what health conditions may be a health. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents.